The role of antibiotics and antibiotic resistance in nature

RI Aminov - Environmental microbiology, 2009 - Wiley Online Library
Investigations of antibiotic resistance from an environmental prospective shed new light on a
problem that was traditionally confined to a subset of clinically relevant antibiotic‐resistant …

Quorum-sensing in Gram-negative bacteria

NA Whitehead, AML Barnard, H Slater… - FEMS microbiology …, 2001 - academic.oup.com
It has become increasingly and widely recognised that bacteria do not exist as solitary cells,
but are colonial organisms that exploit elaborate systems of intercellular communication to …

Quorum sensing, communication and cross-kingdom signalling in the bacterial world

P Williams - Microbiology, 2007 - microbiologyresearch.org
Although unicellular, bacteria are highly interactive and employ a range of cell-to-cell
communication or 'quorum sensing (QS)'systems for promoting collective behaviour within a …

Antibiotics as signal molecules

D Romero, MF Traxler, D López, R Kolter - Chemical reviews, 2011 - ACS Publications
Over the last five decades, the overuse of antibiotics has led to widespread resistance in
pathogenic bacteria. This resistance, combined with slow progress in designing new …

Bacterial gliding motility: multiple mechanisms for cell movement over surfaces

MJ McBride - Annual Reviews in Microbiology, 2001 - annualreviews.org
▪ Abstract The mechanisms responsible for bacterial gliding motility have been a mystery for
almost 200 years. Gliding bacteria move actively over surfaces by a process that does not …

Biosynthesis of carbapenem antibiotic and prodigiosin pigment in Serratia is under quorum sensing control

NR Thomson, MA Crow, SJ McGowan… - Molecular …, 2000 - Wiley Online Library
Serratia sp. ATCC 39006 produces the carbapenem antibiotic, carbapen‐2‐em‐3‐
carboxylic acid and the red pigment, prodigiosin. We have previously reported the …

The enzymes of β-lactam biosynthesis

RB Hamed, JR Gomez-Castellanos, L Henry… - Natural product …, 2013 - pubs.rsc.org
Covering: up to May 2012The β-lactam antibiotics and related β-lactamase inhibitors are
amongst the most important small molecules in clinical use. Most, but not all, β-lactams …

Quorum sensing as a population-density-dependent determinant of bacterial physiology

S Swift, JA Downie, NA Whitehead, AML Barnard… - 2001 - Elsevier
The discovery that bacterial cells can communicate with each other has led to the realization
that bacteria are capable of exhibiting much more complex patterns of co-operative …

Quorum sensing in Serratia

R Van Houdt, M Givskov… - FEMS microbiology …, 2007 - academic.oup.com
Many bacteria use cell–cell communication to monitor their population density, synchronize
their behaviour and socially interact. This communication results in a coordinated gene …

Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights

J Masschelein, M Jenner, GL Challis - Natural product reports, 2017 - pubs.rsc.org
Covering: up to 2017 The overwhelming majority of antibiotics in clinical use originate from
Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have …