With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …

The codon composition of the coding sequence's (ORF) 5′ end first few dozen codons is
known to be distinct to that of the rest of the ORF. Various explanations for the unusual …

The polypeptide exit tunnel is an important functional compartment of the ribosome where
the newly synthesized proteins are surveyed. The tunnel is the target of clinically important …

As nascent polypeptide chains are synthesized, they pass through a tunnel in the large
ribosomal subunit. Interaction between specific nascent chains and the ribosomal tunnel is …

RNA molecules are important cellular components involved in many fundamental biological
processes. Understanding the mechanisms behind their functions requires RNA tertiary …

The ribosome is able to monitor the structure of the nascent peptide and can stall in
response to specific peptide sequences. Such programmed stalling is used for the …

Bacterial infections are characterized by their rapid and widespread proliferation, leading to
significant morbidity. Despite the availability of a variety of antimicrobial drugs, the …

In living systems, polypeptide chains are synthesised on ribosomes, molecular machines
composed of over 50 protein and nucleic acid molecules. As nascent chains emerge from …

The ability to monitor the nascent peptide structure and to respond functionally to specific
nascent peptide sequences is a fundamental property of the ribosome. An extreme …