Endothelial tight junctions (TJs) regulate the transport of water, ions, and molecules through
the paracellular pathway, serving as an important barrier in blood vessels and maintaining …

Claudins are a tetraspan membrane protein multigene family that plays a structural and
functional role in constructing tight junctions. Claudins perform crucial roles in maintaining …

Background The prognosis of esophageal adenocarcinoma (EAC) and gastric
adenocarcinoma (GAC) remains poor, and new therapeutic approaches are urgently …

Tight junctions (TJs) are an important component of cell connectivity; they maintain cell
polarity, permeability and adhesion, and participate in the regulation of cell proliferation and …

Background We have previously described CLDN6 as a tumor suppressor gene in breast
cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly …

Abstract Purpose: Claudin-6 (CLDN6) is expressed at elevated levels in multiple human
cancers including ovarian and endometrial malignancies, with little or no detectable …

Colorectal cancer (CRC) is one of the most common cancers in the world. Abnormal
proliferation is a chief characteristic of cancer and is the initiation of CRC progression. As an …

Background The claudin family is a group of transmembrane proteins related to tight
junctions. While their involvement in cancer has been studied extensively, their relationship …

As a member of the tight junction family, CLDN6 is a tumor suppressor in breast cancer, but
its role in colon cancer is unknown. In this research, we aimed at revealing the function of …

Aberrant expression of the tight junction protein claudin 6 (CLDN6) is a hallmark of gastric
cancer progression. Its expression is regulated by the cAMP response element-binding …