Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens
currently in clinical use. However, the precise mechanisms of DOX's action are not fully …

Selenium is an essential trace element for regulating immune functions through redox-
regulating activity of selenoproteins (eg glutathione peroxidase), protecting immune cells …

Breast cancer has become one of the top five commonest causes of cancer death. The use
of ferroptosis to induce the generation of reactive oxygen species (ROS) in cancer cells …

Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …

Hypoxia has been firmly correlated to the drug resistance of solid tumors. Alleviation of
hypoxia by tumor reoxygenation is expected to sensitize the chemotherapy toward solid …

Doxorubicin (DOX) is a chemotherapeutic agent frequently used for the treatment of a variety
of tumor types, such as breast cancer. Despite the long history of DOX, the mechanistic …

The production of reactive species is a core of the redox cycling profile of anthracyclines.
However, these molecular characteristics can be viewed as a double‐edged sword acting …

Doxorubicin is a widely used and promising anticancer drug; however, a severe dose-
dependent cardiotoxicity hampers its therapeutic value. Doxorubicin may cause acute and …

Background and objective Doxorubicin (DOX) is an anthracycline antitumor antibiotic widely
utilized in treating various tumors. Nevertheless, the toxicity of DOX toward normal cells …

Although chemotherapy and photodynamic therapy (PDT) have been developed for fighting
cancer, the complex and heterogeneous nature of tumors makes it difficult for a single …