The emergence and spread of antibiotic resistance is one of the biggest challenges in public
health. There is an urgent need to discover novel agents against the occurrence of multidrug …

Within the canonical repertoire of the amino acid involved in protein biogenesis, proline
plays a unique role as an amino acid presenting a modified backbone rather than a side …

Natural nonproteinogenic amino acids vastly outnumber the well-known 22 proteinogenic
amino acids. Such amino acids are generated in specialized metabolic pathways. In these …

Covering: from 2000 up to the very early part of 2023 S-Adenosyl-L-methionine (SAM) is a
naturally occurring trialkyl sulfonium molecule that is typically associated with biological …

Azetidines represent one of the most important four-membered heterocycles used in organic
synthesis and medicinal chemistry. The reactivity of azetidines is driven by a considerable …

Covering: 2000 to up to 2023 α, β-Dehydroamino acids (dhAAs) are unsaturated
nonproteinogenic amino acids found in a wide array of naturally occurring peptidyl …

The synthesis of 2‐azetidinones (β‐lactams) from simple acrylamide starting materials by
visible‐light‐mediated energy transfer catalysis is reported. The reaction features a C (sp3) …

The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of airway infection
in cystic fibrosis (CF) patients. P. aeruginosa employs several hierarchically arranged and …

The caseinolytic protease (ClpP) is part of a highly conserved proteolytic complex whose
disruption can lead to antibacterial activity but for which few specific inhibitors have been …

Arsinothricin is a potent antibiotic secreted by soil bacteria. The biosynthesis of arsinothricin
was proposed to involve a C–As bond formation between trivalent As and the 3-amino-3 …