Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …

The action potential of the squid giant axon is formed by just two voltage-dependent
conductances in the cell membrane, yet mammalian central neurons typically express more …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

The hippocampal theta rhythm plays important roles in information processing; however, the
mechanisms of its generation are not well understood. We developed a data-driven …

CA3–CA3 recurrent excitatory synapses are thought to play a key role in memory storage
and pattern completion. Whether the plasticity properties of these synapses are consistent …

High-frequency bursts of action potentials (APs) are a distinctive form of signaling in various
types of mammalian central neurons. In CA1 hippocampal pyramidal neurons in vivo, such …

Recent data indicate that T-type Ca2+ channels are amplifiers of peripheral pain signals, but
their involvement in disorders of sensory neurons such as those associated with diabetes is …

Depending on the behavioral state, hippocampal CA1 pyramidal neurons receive very
distinct patterns of synaptic input and likewise produce very different output patterns. We …

The input–output relationship of neuronal networks depends both on their synaptic
connectivity and on the intrinsic properties of their neuronal elements. In addition to altered …

The roles of voltage-sensitive sodium (Na) and calcium (Ca) channels located on dendrites
and spines in regulating synaptic signals are largely unknown. Here we use 2-photon …