Cough is one of the most common presenting symptoms of COVID-19, along with fever and
loss of taste and smell. Cough can persist for weeks or months after SARS-CoV-2 infection …

Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Background Gefapixant is an oral P2X 3 receptor antagonist that has previously shown
efficacy and safety in refractory chronic cough and unexplained chronic cough. We therefore …

The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by
ATP. Three subunits compose a receptor channel. Each subunit is a polypeptide consisting …

Chronic cough is defined in adults as a cough that lasts for≥ 8 weeks. When it proves
intractable to standard-of-care treatment, it can be referred to as refractory chronic cough …

Background ATP acting via P2X3 receptors is an important mediator of refractory chronic
cough (RCC). This phase 2a double-blinded crossover study assessed the safety …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic
since early 2020. The coronavirus disease 2019 (COVID-19) has already caused more than …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Introduction: Patients with chronic cough experience considerable burden. The cough
severity visual analog scale (VAS) records patients' assessment of cough severity on a 100 …

Abstract ATP-dependent P2X3 receptors play a crucial role in the sensitization of nerve
fibers and pathological pain pathways. They are also involved in pathways triggering cough …