With rapid advances in computer algorithms and hardware, fast and accurate virtual
screening has led to a drastic acceleration in selecting potent small molecules as drug …

Abstract Although Chemical Exchange Saturation Transfer (CEST) type NMR experiments
have been used to study chemical exchange processes in molecules since the early 1960s …

O-Methyl (Nm) is a highly abundant post-transcriptional RNA modification that plays
important biological roles through mechanisms that are not entirely understood. There is …

Riboswitches control gene expression through ligand-dependent structural rearrangements
of the sensing aptamer domain. However, we found that the Bacillus cereus fluoride …

The synthetic neomycin‐sensing riboswitch interacts with its cognate ligand neomycin as
well as with the related antibiotics ribostamycin and paromomycin. Binding of these …

The phenomenon of chemical or conformational exchange in NMR spectroscopy has
enabled detailed characterization of time-dependent aspects of biomolecular function …

This review describes off-resonance R 1ρ relaxation dispersion NMR methods for
characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …

N 6-Methyladenosine (m6A) is an abundant epitranscriptomic modification that plays
important roles in many aspects of RNA metabolism. While m6A is thought to mainly function …

An ever‐increasing number of functional RNAs require a mechanistic understanding. RNA
function relies on changes in its structure, so‐called dynamics. To reveal dynamic processes …

MicroRNAs are evolutionarily conserved small, noncoding RNAs that regulate diverse
biological processes. Due to their essential regulatory roles, microRNA biogenesis is tightly …