Oxidative stress can be induced by various stimuli and altered in certain conditions,
including exercise and pain. Although many studies have investigated oxidative stress in …

In everyday clinical practice, healthcare professionals often meet chronic pain patients with
a poor nutritional status. A poor nutritional status such as malnutrition, unhealthy dietary …

Chronic pain is sustained, in part, through the intricate process of central sensitization (CS),
marked by maladaptive neuroplasticity and neuronal hyperexcitability within central pain …

Pain is an individualized experience for the person suffering from chronic pain. Significant
strides have been made in the last few decades in understanding various biological …

Work-related stress is a growing health problem in modern society. The stress response is
characterized by numerous neurochemicals, neuroendocrine and immune modifications that …

Accumulating evidence suggests that epigenetic mechanisms may hold great potential in
the field of pain. We systematically reviewed the literature exploring epigenetic mechanisms …

Exercise-induced hypoalgesia refers to a reduction in pain sensitivity following a single bout
of exercise, which has been shown to be diminished or impaired with aging and chronic …

Fibromyalgia (FM) is a chronic pain syndrome that affects the central nervous system and
generates disability, which is characterized by generalized pain, fatigue, and functional …

The multiple comorbidities & dimensions of chronic pain present a formidable challenge in
disentangling its aetiology. Here, we performed genome-wide association studies of 8 …

The hypothesis that pain can predispose to frailty development has been recently
investigated in several clinical studies suggesting that frailty and pain may share some …