Chimerism analysis has become an important tool for the peri-transplant surveillance of
engraftment. It offers the possibility to realize impending graft rejection and can serve as an …

RAS has been shown to increase radiation resistance. Upstream and downstream pathways
from RAS could thus be targets for manipulation of radiosensitivity. EGFR expression and …

Constitutive tyrosine kinase activity of Bcr-Abl promotes proliferation and survival of chronic
myelogenous leukemia (CML) cells. Inhibition of Bcr-Abl tyrosine kinase activity or signaling …

Although targeted therapy is yielding promising results in the treatment of specific cancers,
drug resistance poses a problem. We develop a mathematical framework that can be used …

In chronic myelogenous leukemia (CML), the development of chromosomal abnormalities in
addition to the Philadelphia chromosome (clonal evolution) is considered by many to be a …

Agrin signals through the muscle-specific receptor tyrosine kinase (MuSK) to cluster
acetylcholine receptors (AChRs) on the postsynaptic membrane of the neuromuscular …

Overexpression of P-glycoprotein, encoded by the MDR1 gene, confers multidrug resistance
(MDR) on cancer cells and is a frequent impediment to successful chemotherapy. Recent …

Imatinib has emerged as the lead compound for clinical development against chronic
myeloid leukemia. Imatinib inhibits the kinase activity of Bcr-Abl, which functions by …

Background: Growth factor receptor-bound protein 2 (Grb2) is a 25 kDa adaptor protein,
which was originally discovered to accomplish basic cellular events such as cell growth, cell …

BACKGROUND Tyrosine kinases, such as c‐KIT, c‐ABL, and platelet‐derived growth factor‐
beta (PDGFR‐β), are important regulators of cell growth. Highly potent and selective …