Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

The oxetane ring is an emergent, underexplored motif in drug discovery that shows attractive
properties such as low molecular weight, high polarity, and marked three-dimensionality …

Benzofuran and 1, 3, 4-oxadiazole are privileged and versatile heterocyclic
pharmacophores which display a broad spectrum of biological and pharmacological …

Among the various bacterial infections, tuberculosis continues to hold center stage. Its
causative agent, Mycobacterium tuberculosis, possesses robust defense mechanisms …

Pks13 was identified as a key enzyme involved in the final step of mycolic acid biosynthesis.
We previously identified antitubercular coumestans that targeted Pks13-TE, and these …

Abstract Structure-based lead optimization is an open challenge in drug discovery, which is
still largely driven by hypotheses and depends on the experience of medicinal chemists …

There is an urgent need for new tuberculosis (TB) treatments, with novel modes of action, to
reduce the incidence/mortality of TB and to combat resistance to current treatments. Through …

The acquired drug resistance by Mycobacterium tuberculosis (M. tuberculosis) to antibiotics
urges the need for developing novel anti-M. tuberculosis drugs that possess novel …

Tuberculosis (TB) is one of the most threatening diseases for humans, however, the drug
treatment strategy for TB has been stagnant and inadequate, which could not meet current …

Identifying small compounds capable of inhibiting Mycobacterium tuberculosis polyketide
synthase 13 (Pks13), in charge of final step of mycolic acid biosynthesis, could lead to the …