Executive summary Every infant, child, and adolescent will experience pain at times
throughout their life. Childhood pain ranges from acute to chronic, and includes procedural …

Background: The management of acute and chronic pain for individuals living with sickle cell
disease (SCD) is a clinical challenge. This reflects the paucity of clinical SCD pain research …

We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …

Background This is an update of the original Cochrane review first published in Issue 1,
2003, and previously updated in 2009, 2012 and 2014. Chronic pain, defined as pain that …

Background Pain is a common feature of childhood and adolescence around the world, and
for many young people, that pain is chronic. The World Health Organization guidelines for …

We know little about the safety or efficacy of pharmacological medicines for children and
adolescents with chronic pain, despite their common use. Our aim was to conduct an …

Chronic pain in childhood is an international public health problem. We conducted a
systematic review and meta-analysis to provide a summary of the published evidence of …

Proteasome inhibitors (PIs), especially bortezomib (BTZ), have come to the forefront over the
last years because of their unprecedented efficacy mainly against multiple myeloma (MM) …

Tapentadol is an analgesic compound that acts centrally to attenuate pain. Previous studies
have shown that tapentadol has dual mechanisms of action as a mu-opioid receptor agonist …

Disorders of the gut-brain interaction negatively impact quality of life and carry a substantial
socioeconomic burden. Irritable bowel syndrome (IBS) and functional abdominal pain-not …