Acute liver failure caused by drug overdose is a significant clinical problem in developed
countries. Acetaminophen (APAP), a widely used analgesic and antipyretic drug, but its …

During inflammation neutrophils become activated and segregate neutrophil serine
proteases (NSPs) to the surrounding environment in order to support a natural immune …

Abstract Background & Aims Patients with severe exacerbation of chronic hepatitis B (SE‐
CHB) are at risk of developing acute‐on‐chronic liver failure (ACLF). Systemic inflammation …

Excessive activation of neutrophils results in the release of neutrophil elastase (NE), which
leads to lung injury in severe pneumonia. Previously, we demonstrated a novel immune …

Affinity chromatography is a powerful technology for phosphopeptide enrichment from body
fluids. Saliva is a non-invasive body fluid for disease diagnosis, while few studies applied …

Hepatocyte death during acetaminophen (APAP) intoxication elicits a reactive inflammatory
response, with hepatic recruitment of neutrophils and monocytes, which further aggravates …

Intense neutrophil infiltration into the liver is a characteristic of acetaminophen-induced
acute liver injury. Neutrophil elastase is released by neutrophils during inflammation. To …

Receptor tyrosine kinases (RTKs) bearing oncogenic mutations in EGFR, ALK and ROS1
occur in a significant subset of lung adenocarcinomas. Tyrosine kinase inhibitors (TKIs) …

Cystic Fibrosis (CF) airway disease is characterized by impaired mucociliary clearance,
chronic, polymicrobial infections and robust, neutrophil-dominated inflammation. Pulmonary …

Serine protease, Human Neutrophil Elastase (HNE), has been shown to be useful in
medical science, however, its over production and malfunctioning may produce devastating …