Integrins as biomechanical sensors of the microenvironment
Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …
Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions
J Alexander, E Cukierman - Current opinion in cell biology, 2016 - Elsevier
Highlights•Innate mesenchymal-stroma maintains a tumor-suppressive homeostatic
equilibrium.•Fibroblastic-ECM interplay is referred to as stromal dynamic reciprocity.• …
equilibrium.•Fibroblastic-ECM interplay is referred to as stromal dynamic reciprocity.• …
Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility
Physical changes in skin are among the most visible signs of aging. We found that young
dermal fibroblasts secrete high levels of extracellular matrix (ECM) constituents, including …
dermal fibroblasts secrete high levels of extracellular matrix (ECM) constituents, including …
Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates
Recent evidence has shown that, in addition to rigidity, the viscous response of the
extracellular matrix (ECM) significantly affects the behavior and function of cells. However …
extracellular matrix (ECM) significantly affects the behavior and function of cells. However …
Machine learning interpretable models of cell mechanics from protein images
Cellular form and function emerge from complex mechanochemical systems within the
cytoplasm. Currently, no systematic strategy exists to infer large-scale physical properties of …
cytoplasm. Currently, no systematic strategy exists to infer large-scale physical properties of …
[HTML][HTML] Viscoelasticity acts as a marker for tumor extracellular matrix characteristics
CT Mierke - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Biological materials such as extracellular matrix scaffolds, cancer cells, and tissues are often
assumed to respond elastically for simplicity; the viscoelastic response is quite commonly …
assumed to respond elastically for simplicity; the viscoelastic response is quite commonly …
Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices
We describe a multiscale model that incorporates force-dependent mechanical plasticity
induced by interfiber cross-link breakage and stiffness-dependent cellular contractility to …
induced by interfiber cross-link breakage and stiffness-dependent cellular contractility to …
Nuclear envelope wrinkling predicts mesenchymal progenitor cell mechano-response in 2D and 3D microenvironments
Exogenous mechanical cues are transmitted from the extracellular matrix to the nuclear
envelope (NE), where mechanical stress on the NE mediates shuttling of transcription …
envelope (NE), where mechanical stress on the NE mediates shuttling of transcription …
Cellular mechanosensing of the biophysical microenvironment: a review of mathematical models of biophysical regulation of cell responses
Cells in vivo reside within complex microenvironments composed of both biochemical and
biophysical cues. The dynamic feedback between cells and their microenvironments hinges …
biophysical cues. The dynamic feedback between cells and their microenvironments hinges …
Ligand mobility-mediated cell adhesion and spreading
Cells live in a highly dynamic environment where their physical connection and
communication with the outside are achieved through receptor–ligands binding. Therefore …
communication with the outside are achieved through receptor–ligands binding. Therefore …