Blood-brain barrier dysfunction and recovery after ischemic stroke
The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …
The vascular basement membrane in the healthy and pathological brain
MS Thomsen, LJ Routhe… - Journal of Cerebral Blood …, 2017 - journals.sagepub.com
The vascular basement membrane contributes to the integrity of the blood-brain barrier
(BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive …
(BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive …
Intensive vs conventional blood pressure lowering after endovascular thrombectomy in acute ischemic stroke: the OPTIMAL-BP randomized clinical trial
Importance Optimal blood pressure (BP) control after successful reperfusion with
endovascular thrombectomy (EVT) for patients with acute ischemic stroke is unclear …
endovascular thrombectomy (EVT) for patients with acute ischemic stroke is unclear …
Molecular pathophysiology of cerebral edema
JA Stokum, V Gerzanich… - Journal of Cerebral Blood …, 2016 - journals.sagepub.com
Advancements in molecular biology have led to a greater understanding of the individual
proteins responsible for generating cerebral edema. In large part, the study of cerebral …
proteins responsible for generating cerebral edema. In large part, the study of cerebral …
[HTML][HTML] Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke
Numerous studies have documented increases in matrix metalloproteinases (MMPs),
specifically MMP-9 levels following stroke, with such perturbations associated with …
specifically MMP-9 levels following stroke, with such perturbations associated with …
Timing of anticoagulation after recent ischaemic stroke in patients with atrial fibrillation
Summary Background About 13–26% of all acute ischaemic strokes are related to non-
valvular atrial fibrillation, the most common cardiac arrhythmia globally. Deciding when to …
valvular atrial fibrillation, the most common cardiac arrhythmia globally. Deciding when to …
Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
The mechanism and long-term consequences of early blood–brain barrier (BBB) disruption
after cerebral ischaemic/reperfusion (I/R) injury are poorly understood. Here we discover …
after cerebral ischaemic/reperfusion (I/R) injury are poorly understood. Here we discover …
Hemorrhagic transformation after ischemic stroke in animals and humans
GC Jickling, DZ Liu, B Stamova… - Journal of Cerebral …, 2014 - journals.sagepub.com
Hemorrhagic transformation (HT) is a common complication of ischemic stroke that is
exacerbated by thrombolytic therapy. Methods to better prevent, predict, and treat HT are …
exacerbated by thrombolytic therapy. Methods to better prevent, predict, and treat HT are …
The blood–brain barrier in health and disease
R Daneman - Annals of neurology, 2012 - Wiley Online Library
The blood–brain barrier (BBB) is a term used to describe a series of properties possessed
by the vasculature of the central nervous system (CNS) that tightly regulate the movement of …
by the vasculature of the central nervous system (CNS) that tightly regulate the movement of …
Pathogenesis of brain edema and investigation into anti-edema drugs
S Michinaga, Y Koyama - International journal of molecular sciences, 2015 - mdpi.com
Brain edema is a potentially fatal pathological state that occurs after brain injuries such as
stroke and head trauma. In the edematous brain, excess accumulation of extracellular fluid …
stroke and head trauma. In the edematous brain, excess accumulation of extracellular fluid …