In vivo methods for imaging blood–brain barrier function and dysfunction

WJ Harris, MC Asselin, R Hinz, LM Parkes… - European journal of …, 2023 - Springer
The blood–brain barrier (BBB) is the interface between the central nervous system and
systemic circulation. It tightly regulates what enters and is removed from the brain …

Measuring water exchange across the blood-brain barrier using MRI

BR Dickie, GJM Parker, LM Parkes - Progress in Nuclear Magnetic …, 2020 - Elsevier
The blood-brain barrier (BBB) regulates the transfer of solutes and essential nutrients into
the brain. Growing evidence supports BBB dysfunction in a range of acute and chronic brain …

Blood–brain barrier breakdown in relationship to Alzheimer and vascular disease

Z Lin, S Sur, P Liu, Y Li, D Jiang, X Hou… - Annals of …, 2021 - Wiley Online Library
Objective Blood–brain barrier (BBB) breakdown has been suggested to be an early
biomarker in human cognitive impairment. However, the relationship between BBB …

Mapping water exchange across the blood–brain barrier using 3D diffusion‐prepared arterial spin labeled perfusion MRI

X Shao, SJ Ma, M Casey, L D'Orazio… - Magnetic resonance …, 2019 - Wiley Online Library
Purpose To present a novel MR pulse sequence and modeling algorithm to quantify the
water exchange rate (kw) across the blood–brain barrier (BBB) without contrast, and to …

Increased serum peripheral C-reactive protein is associated with reduced brain barriers permeability of TSPO radioligands in healthy volunteers and depressed …

FE Turkheimer, N Althubaity, J Schubert… - Brain, behavior, and …, 2021 - Elsevier
The relationship between peripheral and central immunity and how these ultimately may
cause depressed behaviour has been the focus of a number of imaging studies conducted …

[HTML][HTML] Sickness behaviour and depression: An updated model of peripheral-central immunity interactions

FE Turkheimer, M Veronese, V Mondelli, D Cash… - Brain, Behavior, and …, 2023 - Elsevier
Current research into mood disorders indicates that circulating immune mediators
participating in the pathophysiology of chronic somatic disorders have potent influences on …

Water exchange rate across the blood‐brain barrier is associated with CSF amyloid‐β 42 in healthy older adults

BT Gold, X Shao, TL Sudduth, GA Jicha… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction We tested if water exchange across the blood‐brain barrier (BBB), estimated
with a noninvasive magnetic resonance imaging (MRI) technique, is associated with …

[HTML][HTML] Non-contrast assessment of blood-brain barrier permeability to water in mice: An arterial spin labeling study at cerebral veins

Z Wei, H Liu, Z Lin, M Yao, R Li, C Liu, Y Li, J Xu… - Neuroimage, 2023 - Elsevier
Blood-brain barrier (BBB) plays a critical role in protecting the brain from toxins and
pathogens. However, in vivo tools to assess BBB permeability are scarce and often require …

Quantification of blood–brain barrier water exchange and permeability with multidelay diffusion‐weighted pseudo‐continuous arterial spin labeling

X Shao, C Zhao, Q Shou… - Magnetic resonance …, 2023 - Wiley Online Library
Purpose To present a pulse sequence and mathematical models for quantification of blood–
brain barrier water exchange and permeability. Methods Motion‐compensated diffusion …

Quantitative water permeability mapping of blood-brain-barrier dysfunction in aging

JN Ford, Q Zhang, EM Sweeney, AE Merkler… - Frontiers in Aging …, 2022 - frontiersin.org
Blood-brain-barrier (BBB) dysfunction is a hallmark of aging and aging-related disorders,
including cerebral small vessel disease and Alzheimer's disease. An emerging biomarker of …