In vivo methods for imaging blood–brain barrier function and dysfunction
WJ Harris, MC Asselin, R Hinz, LM Parkes… - European journal of …, 2023 - Springer
The blood–brain barrier (BBB) is the interface between the central nervous system and
systemic circulation. It tightly regulates what enters and is removed from the brain …
systemic circulation. It tightly regulates what enters and is removed from the brain …
Measuring water exchange across the blood-brain barrier using MRI
The blood-brain barrier (BBB) regulates the transfer of solutes and essential nutrients into
the brain. Growing evidence supports BBB dysfunction in a range of acute and chronic brain …
the brain. Growing evidence supports BBB dysfunction in a range of acute and chronic brain …
Blood–brain barrier breakdown in relationship to Alzheimer and vascular disease
Objective Blood–brain barrier (BBB) breakdown has been suggested to be an early
biomarker in human cognitive impairment. However, the relationship between BBB …
biomarker in human cognitive impairment. However, the relationship between BBB …
Mapping water exchange across the blood–brain barrier using 3D diffusion‐prepared arterial spin labeled perfusion MRI
Purpose To present a novel MR pulse sequence and modeling algorithm to quantify the
water exchange rate (kw) across the blood–brain barrier (BBB) without contrast, and to …
water exchange rate (kw) across the blood–brain barrier (BBB) without contrast, and to …
Increased serum peripheral C-reactive protein is associated with reduced brain barriers permeability of TSPO radioligands in healthy volunteers and depressed …
FE Turkheimer, N Althubaity, J Schubert… - Brain, behavior, and …, 2021 - Elsevier
The relationship between peripheral and central immunity and how these ultimately may
cause depressed behaviour has been the focus of a number of imaging studies conducted …
cause depressed behaviour has been the focus of a number of imaging studies conducted …
[HTML][HTML] Sickness behaviour and depression: An updated model of peripheral-central immunity interactions
Current research into mood disorders indicates that circulating immune mediators
participating in the pathophysiology of chronic somatic disorders have potent influences on …
participating in the pathophysiology of chronic somatic disorders have potent influences on …
Water exchange rate across the blood‐brain barrier is associated with CSF amyloid‐β 42 in healthy older adults
Introduction We tested if water exchange across the blood‐brain barrier (BBB), estimated
with a noninvasive magnetic resonance imaging (MRI) technique, is associated with …
with a noninvasive magnetic resonance imaging (MRI) technique, is associated with …
[HTML][HTML] Non-contrast assessment of blood-brain barrier permeability to water in mice: An arterial spin labeling study at cerebral veins
Blood-brain barrier (BBB) plays a critical role in protecting the brain from toxins and
pathogens. However, in vivo tools to assess BBB permeability are scarce and often require …
pathogens. However, in vivo tools to assess BBB permeability are scarce and often require …
Quantification of blood–brain barrier water exchange and permeability with multidelay diffusion‐weighted pseudo‐continuous arterial spin labeling
Purpose To present a pulse sequence and mathematical models for quantification of blood–
brain barrier water exchange and permeability. Methods Motion‐compensated diffusion …
brain barrier water exchange and permeability. Methods Motion‐compensated diffusion …
Quantitative water permeability mapping of blood-brain-barrier dysfunction in aging
Blood-brain-barrier (BBB) dysfunction is a hallmark of aging and aging-related disorders,
including cerebral small vessel disease and Alzheimer's disease. An emerging biomarker of …
including cerebral small vessel disease and Alzheimer's disease. An emerging biomarker of …