The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

Tissue development and homeostasis are governed by the actions of stem cells. Multipotent
cells are capable of self-renewal during the course of one's lifetime. The accurate and …

Breast cancer is the most common form of cancer diagnosed in women worldwide and the
second leading cause of cancer-related deaths in the USA. Despite the development of …

Wnt signaling regulates a variety of cellular processes, including cell fate, differentiation,
proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many …

Mammary gland development occurs through distinctive stages throughout embryonic and
pubertal development and reproductive life. At each stage, different signals are required to …

Adult stem cells have the ability to self-renew and to generate specialized cells. Self-renewal
is dependent on extrinsic niche factors but few of those signals have been identified. In …

Breast cancer continues to be a serious health problem particularly in developed countries.
Of particular concern is triple negative breast cancer (TNBC) which does not respond well to …

Human mesenchymal stem cells (hMSCs) can home to tumor sites and inhibit the growth of
tumor cells. Little is known about the underlying molecular mechanisms that link hMSCs to …

The mammary gland is one of the most regenerative organs in the body, with the majority of
development occurring postnatally and in the adult mammal. Formation of the ductal tree is …