Abstract Peripheral myelin protein-22 (PMP22) is primarily expressed in the compact myelin
of the peripheral nervous system. Levels of PMP22 have to be tightly regulated since …

DGKs (diacylglycerol kinases) are members of a unique and conserved family of
intracellular lipid kinases that phosphorylate DAG (diacylglycerol), catalysing its conversion …

N6-methyladenosine (m 6 A) is the most pervasive RNA modification and is recognized as a
novel epigenetic regulation in RNA metabolism. Although the m 6 A modification involves …

FoxO transcription factors have a conserved role in longevity, and act as tissue-specific
tumor suppressors in mammals. Several nodes of interaction have been identified between …

The p53 tumor suppressor restricts tumorigenesis through the transcriptional activation of
target genes involved in cell-cycle arrest and apoptosis. Here, we identify Prl-3 …

Stroke is a common cause of death and serious long-term adult disability. Oxidative DNA
damage is a severe consequence of oxidative stress associated with ischemic stroke. The …

The tumour suppressor alternative reading frame (ARF) is one of the most frequently
mutated proteins in human cancer. It has been well established that ARF is able to stabilize …

Lysophosphatidic acid (LPA) promotes cell survival through the activation of G protein-
coupled LPA receptors. However, whether different LPA receptors activate distinct anti …

Background Central nervous system axons lack a robust regenerative response following
spinal cord injury (SCI) and regeneration is usually abortive. Supraspinal pathways, which …

Purpose: Plumbagin is thought to be a bioactive phytochemical drug and exerts an antitumor
effect on various cancers. However, few studies focus on the antitumor activity of plumbagin …