What is life without oxygen is a rhetorical question. On the other hand, unraveling the
intricacies and understanding the various mechanisms underpinning the biological …

Biocatalysis is an enabling technology adding to organic oxidation chemistry. Especially the
high selectivity of enzymatic oxidation coevally operating under mild conditions and not …

Abstract Baeyer–Villiger monooxygenases (BVMOs) represent a specific class of
monooxygenases that are capable of catalyzing a variety of oxidation reactions, including …

Glycosyltransferases are a superfamily of enzymes that are notoriously difficult to inhibit.
Here we apply an mRNA display technology integrated with genetic code reprogramming …

Morphinan alkaloids from the opium poppy are used for pain relief. The direction of
metabolites to morphinan biosynthesis requires isomerization of (S)-to (R)-reticuline …

Baeyer–Villiger monooxygenases For many enzyme classes, a wealth of information on, for
example, structure and mechanism has been generated in the last few decades. While the …

Over the past few years, industrial interest in biocatalysts that perform selective oxidative
reactions has increased significantly.[1] Baeyer–Villiger monooxygenases (BVMOs) have …

Modern tools for enzyme discovery and protein engineering substantially broadened the
number of enzymes applicable for biocatalysis and helped to alter their properties such as …

Enzymatic cleavage of the glycosidic bond yields products in which the anomeric
configuration is either retained or inverted. Each mechanism reflects the dispositions of the …

Background: Ethionamide and prothionamide are now included in group C of the WHO
recommended drugs for the treatment of tuberculosis resistant to rifampicin and multidrug …