In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

For decades, it was commonly accepted that the brain is secluded from peripheral immune
activity and is self-sufficient for its maintenance and repair. This simplistic perception was …

The central nervous system (CNS) comprises the brain, spinal cord, optic nerves and retina,
and contains post-mitotic, delicate cells. As the rigid coverings of the CNS render swelling …

Glioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is
notoriously resistant to immunotherapy mainly due to its unique immune microenvironment …

Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …

Immune responses in the CNS are common, despite its perception as a site of immune
privilege. These responses can be mediated by resident microglia and astrocytes, which are …

In response to a peripheral infection, innate immune cells produce pro-inflammatory
cytokines that act on the brain to cause sickness behaviour. When activation of the …

In this perspective, I review recent evidence that glial cells are critical participants in every
major aspect of brain development, function, and disease. Far more active than once …

Brain endothelial cells are unique among endothelial cells in that they express apical
junctional complexes, including tight junctions, which quite resemble epithelial tight …

Immune cells mediate critical inflammatory and neurodegenerative processes in the CNS in
individuals with multiple sclerosis (MS). In MS, activated microglia, border-associated …