Current cancer management strategies fail to adequately treat malignancies with
multivariable dose-restricting factors such as systemic toxicity and multi-drug resistance …

Cancer is one of the main reasons of death in the most countries and in Iran. Immunotherapy
quickly became one of the best methods of cancer treatment, along with chemotherapy and …

Immunotoxins (ITs) are attractive anticancer modalities aimed at cancer-specific delivery of
highly potent cytotoxic protein toxins. An IT consists of a targeting domain (an antibody …

Conventional anticancer therapeutics often suffer from lack of specificity, resulting in
toxicities to normal healthy tissues and poor therapeutic index. Antibody-mediated delivery …

Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as
saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and …

Fibroblast activation protein (FAP) is highly expressed in the tumor‐associated fibroblasts
(TAFs) of most human epithelial cancers. FAP plays a critical role in tumorigenesis and …

B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells
resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation …

Introduction: Brain tumors are inherently difficult to treat in large part due to the cellular blood–
brain barriers (BBBs) that limit the delivery of therapeutics to the tumor tissue from the …

The term ribosome-inactivating protein (RIP) is used to denominate proteins mostly of plant
origin, which have N-glycosidase enzymatic activity leading to a complete destruction of the …

The eukaryotic green algae, Chlamydomonas reinhardtii has been shown to be capable of
producing a variety of recombinant proteins, but the true potential of this platform remains …