Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …

Cellular actions of thyroid hormone may be initiated within the cell nucleus, at the plasma
membrane, in cytoplasm, and at the mitochondrion. Thyroid hormone nuclear receptors …

The use of nanomedicine for antitumor therapy has been extensively investigated for a long
time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently …

The application of nanotechnology to medicine, commonly referred to as 'nanomedicine',
has the potential to transform our approach to human health and disease. Research at the …

Integrin αvβ3, a cell surface receptor, participates in signaling transduction pathways in
cancer cell proliferation and metastasis. Several ligands bind to integrin αvβ3 to regulate …

Plasma membrane integrin αvβ3 is a cell surface receptor for thyroid hormone at which
nongenomic actions are initiated. L-thyroxine (T4) and 3, 3′, 5-triiodo-L-thyronine (T3) …

In conventional drug administration, drug molecules cross multiple biological barriers,
distribute randomly in the tissues, and can release insufficient concentrations at the desired …

Integrin αvβ3 is generously expressed by cancer cells and rapidly dividing endothelial cells.
The principal ligands of the integrin are extracellular matrix proteins, but we have described …

Context: Tetraiodothyroacetic acid (tetrac) blocks angiogenic and tumor cell proliferation
actions of thyroid hormone initiated at the cell surface hormone receptor on integrin αvβ3 …

Thyroid hormones play important roles in regulating normal metabolism, development, and
growth. They also stimulate cancer cell proliferation. Their metabolic and developmental …