ABC family transporters
X Liu - Drug transporters in drug disposition, effects and …, 2019 - Springer
The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …
living organisms. The processes are usually mediated by specific transporters. One of the …
Calcineurin inhibitor nephrotoxicity
The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in
the field of transplantation, with excellent short-term outcome. However, the chronic …
the field of transplantation, with excellent short-term outcome. However, the chronic …
Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature
ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …
Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
SF Zhou - Xenobiotica, 2008 - Taylor & Francis
1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …
Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Calcineurin Inhibitors: Part I
The calcineurin inhibitors ciclosporin (cyclosporine) and tacrolimus are immunosuppressant
drugs used for the prevention of organ rejection following transplantation. Both agents are …
drugs used for the prevention of organ rejection following transplantation. Both agents are …
PharmGKB summary: cyclosporine and tacrolimus pathways
JM Barbarino, CE Staatz… - Pharmacogenetics …, 2013 - journals.lww.com
Tacrolimus (FK506) and cyclosporine (cyclosporin A, CsA) are cornerstone
immunosuppressive agents administered to solid organ transplant recipients to prevent and …
immunosuppressive agents administered to solid organ transplant recipients to prevent and …
Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: implications in …
K Kurose, E Sugiyama, Y Saito - Drug metabolism and …, 2012 - jstage.jst.go.jp
Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …
development time and application review time. The former factor is still an important problem …
Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs
I Cascorbi - Pharmacology & therapeutics, 2006 - Elsevier
Interindividual differences of drug response are an important cause of treatment failures and
adverse drug reactions. The identification of polymorphisms explaining distinct phenotypes …
adverse drug reactions. The identification of polymorphisms explaining distinct phenotypes …
ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research
GD Leschziner, T Andrew, M Pirmohamed… - The …, 2007 - nature.com
The product of the ABCB1 gene, P-glycoprotein (PGP), is a transmembrane active efflux
pump for a variety of drugs. It is a putative mechanism of multidrug resistance in a range of …
pump for a variety of drugs. It is a putative mechanism of multidrug resistance in a range of …
Significance of the minor cytochrome P450 3A isoforms
AK Daly - Clinical pharmacokinetics, 2006 - Springer
Abstract Cytochrome P450 (CYP) 3A4 is responsible for most CYP3A-mediated drug
metabolism but the minor isoforms CYP3A5, CYP3A7 and CYP3A43 also contribute …
metabolism but the minor isoforms CYP3A5, CYP3A7 and CYP3A43 also contribute …