Members of the NDR (nuclear Dbf2-related) protein-kinase family are essential components
of pathways that control important cellular processes, such as morphological changes …

Here, we will review the evidence showing that mitotic exit is initiated by regulated
proteolysis and then driven by the PPP family of phosphoserine/threonine phosphatases …

After an introductory section, this article will focus on four questions: How should the Kyoto
School be defined? What is meant by its central philosophical concept of “absolute …

Mitosis requires precise coordination of multiple global reorganizations of the nucleus and
cytoplasm. Cyclin-dependent kinase 1 (Cdk1) is the primary upstream kinase that directs …

CDC14 was originally identified by L. Hartwell in his famous screen for genes that regulate
the budding yeast cell cycle. Subsequent work showed that Cdc14 belongs to a family of …

Simple Summary Cancer is increasingly viewed as a cell cycle disease in that the
dysregulation of the cell cycle machinery is a common feature in cancer. The Hippo …

Abstract “Functional homology” appears regularly in different areas of biological research
and yet it is apparently a contradiction in terms—homology concerns identity of structure …

Entry into mitosis of the eukaryotic cell cycle is driven by rising cyclin-dependent kinase
(Cdk) activity. During exit from mitosis, Cdk activity must again decline. Cdk downregulation …

Recent work has highlighted the important role played by protein phosphatase complexes in
the regulation of mitosis from yeast to mammals. There have been important advances in …

Maintenance of genome integrity is fundamental for cellular physiology. Our hereditary
information encoded in the DNA is intrinsically susceptible to suffer variations, mostly due to …