The majority of human energy metabolism occurs in skeletal muscle mitochondria
emphasizing the importance of understanding the regulation of myocellular mitochondrial …

Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect
organisms against various noxious stimuli including DNA damage, oxidative stress …

Background Irisin is a novel exercise-induced myokine involved in the regulation of adipose
browning and thermogenesis. In this study, we investigated the potential role of irisin in …

How exercise elicits systemic metabolic benefits in both muscles and non-contractile tissues
is unclear. Autophagy is a stress-induced lysosomal degradation pathway that mediates …

Exercise is among the most effective interventions for age-associated mobility decline and
metabolic dysregulation. Although long-term endurance exercise promotes insulin sensitivity …

Instability and excessive use of the knee joint can cause osteoarthritis (OA). Reasonable
exercise can enhance the stability of the knee joint and prevent and relieve the occurrence …

Maintaining nutrient and energy homeostasis is crucial for the survival and function of cells
and organisms in response to environmental stress. Cells have evolved a stress-induced …

Physical activity has been found to aid the maintenance of health in the elderly. Exercise-
induced skeletal muscle contractions lead to the production and secretion of many small …

Skeletal muscle is a highly malleable tissue capable of altering its phenotype in response to
external stimuli including exercise. This response is determined by the mode,(endurance …

The merits of exercise on muscle health and well-being are numerous and well
documented. However, the mechanisms underlying the robust adaptations induced by …