The role of m6A modification in the biological functions and diseases

X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …

The role of adult hippocampal neurogenesis in brain health and disease

T Toda, SL Parylak, SB Linker, FH Gage - Molecular psychiatry, 2019 - nature.com
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Exosome mediated delivery of miR-124 promotes neurogenesis after ischemia

J Yang, X Zhang, X Chen, L Wang, G Yang - Molecular Therapy-Nucleic …, 2017 - cell.com
The intrinsic ability of neurogenesis after stroke has been proven weak, which results in
insufficient repair of injury in the nerve system. Recent studies suggest multiple microRNAs …

Adult mammalian neural stem cells and neurogenesis: five decades later

AM Bond, G Ming, H Song - Cell stem cell, 2015 - cell.com
Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and
enhance plasticity. Since its initial discovery five decades ago, investigations of adult …

Adult neurogenesis in the mammalian brain: significant answers and significant questions

G Ming, H Song - Neuron, 2011 - cell.com
Adult neurogenesis, a process of generating functional neurons from adult neural
precursors, occurs throughout life in restricted brain regions in mammals. The past decade …

Adult neurogenesis contributes to hippocampal plasticity

T Toda, FH Gage - Cell and tissue research, 2018 - Springer
Adult hippocampal neurogenesis is the process by which new functional neurons are added
to the adult dentate gyrus of the hippocampus. Animal studies have shown that the degree of …

Epigenetic mechanisms in neurogenesis

B Yao, KM Christian, C He, P Jin, G Ming… - Nature reviews …, 2016 - nature.com
In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …

The epigenetics of aging and neurodegeneration

R Lardenoije, A Iatrou, G Kenis, K Kompotis… - Progress in …, 2015 - Elsevier
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Cell cycle regulation of stem cells by microRNAs

MMJ Mens, M Ghanbari - Stem cell reviews and reports, 2018 - Springer
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the
regulation of gene expression. They are involved in the fine-tuning of fundamental biological …

MicroRNAs in neural development: from master regulators to fine-tuners

M Rajman, G Schratt - Development, 2017 - journals.biologists.com
The proper formation and function of neuronal networks is required for cognition and
behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to …