Mass spectrometry approaches to glycomic and glycoproteomic analyses
Glycomic and glycoproteomic analyses involve the characterization of oligosaccharides
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …
Glycosylation of extracellular vesicles: current knowledge, tools and clinical perspectives
It is now acknowledged that extracellular vesicles (EVs) are important effectors in a vast
number of biological processes through intercellular transfer of biomolecules. Increasing …
number of biological processes through intercellular transfer of biomolecules. Increasing …
Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health
This study indicates that glycosylation of immunoglobulin G, the most abundant antibody in
human blood, may convey useful information with regard to inflammation and metabolic …
human blood, may convey useful information with regard to inflammation and metabolic …
N‐glycome signatures in human plasma: associations with physiology and major diseases
N‐glycome analysis in total plasma or serum yields information about the levels and
glycosylation patterns of major plasma glycoproteins, including immunoglobulins, acute …
glycosylation patterns of major plasma glycoproteins, including immunoglobulins, acute …
Global and site‐specific analysis of protein glycosylation in complex biological systems with Mass Spectrometry
H Xiao, F Sun, S Suttapitugsakul… - Mass spectrometry …, 2019 - Wiley Online Library
Protein glycosylation is ubiquitous in biological systems and plays essential roles in many
cellular events. Global and site‐specific analysis of glycoproteins in complex biological …
cellular events. Global and site‐specific analysis of glycoproteins in complex biological …
Plasma N-glycan signatures are associated with features of inflammatory bowel diseases
Background & Aims Biomarkers are needed for early detection of Crohn's disease (CD) and
ulcerative colitis (UC) or to predict patient outcomes. Glycosylation is a common and …
ulcerative colitis (UC) or to predict patient outcomes. Glycosylation is a common and …
High-throughput serum N-glycomics: method comparison and application to study rheumatoid arthritis and pregnancy-associated changes*[S]
KR Reiding, A Bondt, R Hennig, RA Gardner… - Molecular & cellular …, 2019 - ASBMB
N-Glycosylation is a fundamentally important protein modification with a major impact on
glycoprotein characteristics such as serum half-life and receptor interaction. More than half …
glycoprotein characteristics such as serum half-life and receptor interaction. More than half …
The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation
A common missense variant in SLC39A8 is convincingly associated with schizophrenia and
several additional phenotypes. Homozygous loss-of-function mutations in SLC39A8 result in …
several additional phenotypes. Homozygous loss-of-function mutations in SLC39A8 result in …
Plasma protein N-glycan signatures of type 2 diabetes
V Dotz, RFH Lemmers, KR Reiding… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Background Little is known about enzymatic N-glycosylation in type 2 diabetes, a common
posttranslational modification of proteins influencing their function and integrating genetic …
posttranslational modification of proteins influencing their function and integrating genetic …
Glycosylation biomarkers associated with age-related diseases and current methods for glycan analysis
Ageing is a complex process which implies the accumulation of molecular, cellular and
organ damage, leading to an increased vulnerability to disease. In Western societies, the …
organ damage, leading to an increased vulnerability to disease. In Western societies, the …