Mass spectrometry approaches to glycomic and glycoproteomic analyses

LR Ruhaak, G Xu, Q Li, E Goonatilleke… - Chemical …, 2018 - ACS Publications
Glycomic and glycoproteomic analyses involve the characterization of oligosaccharides
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …

Glycosylation of extracellular vesicles: current knowledge, tools and clinical perspectives

C Williams, F Royo, O Aizpurua-Olaizola… - Journal of …, 2018 - Taylor & Francis
It is now acknowledged that extracellular vesicles (EVs) are important effectors in a vast
number of biological processes through intercellular transfer of biomolecules. Increasing …

Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health

R Plomp, LR Ruhaak, HW Uh, KR Reiding, M Selman… - Scientific reports, 2017 - nature.com
This study indicates that glycosylation of immunoglobulin G, the most abundant antibody in
human blood, may convey useful information with regard to inflammation and metabolic …

N‐glycome signatures in human plasma: associations with physiology and major diseases

V Dotz, M Wuhrer - FEBS letters, 2019 - Wiley Online Library
N‐glycome analysis in total plasma or serum yields information about the levels and
glycosylation patterns of major plasma glycoproteins, including immunoglobulins, acute …

Global and site‐specific analysis of protein glycosylation in complex biological systems with Mass Spectrometry

H Xiao, F Sun, S Suttapitugsakul… - Mass spectrometry …, 2019 - Wiley Online Library
Protein glycosylation is ubiquitous in biological systems and plays essential roles in many
cellular events. Global and site‐specific analysis of glycoproteins in complex biological …

Plasma N-glycan signatures are associated with features of inflammatory bowel diseases

F Clerc, M Novokmet, V Dotz, KR Reiding, N de Haan… - Gastroenterology, 2018 - Elsevier
Background & Aims Biomarkers are needed for early detection of Crohn's disease (CD) and
ulcerative colitis (UC) or to predict patient outcomes. Glycosylation is a common and …

High-throughput serum N-glycomics: method comparison and application to study rheumatoid arthritis and pregnancy-associated changes*[S]

KR Reiding, A Bondt, R Hennig, RA Gardner… - Molecular & cellular …, 2019 - ASBMB
N-Glycosylation is a fundamentally important protein modification with a major impact on
glycoprotein characteristics such as serum half-life and receptor interaction. More than half …

The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation

RG Mealer, BG Jenkins, CY Chen, MJ Daly, T Ge… - Scientific Reports, 2020 - nature.com
A common missense variant in SLC39A8 is convincingly associated with schizophrenia and
several additional phenotypes. Homozygous loss-of-function mutations in SLC39A8 result in …

Plasma protein N-glycan signatures of type 2 diabetes

V Dotz, RFH Lemmers, KR Reiding… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Background Little is known about enzymatic N-glycosylation in type 2 diabetes, a common
posttranslational modification of proteins influencing their function and integrating genetic …

Glycosylation biomarkers associated with age-related diseases and current methods for glycan analysis

B Paton, M Suarez, P Herrero, N Canela - International Journal of …, 2021 - mdpi.com
Ageing is a complex process which implies the accumulation of molecular, cellular and
organ damage, leading to an increased vulnerability to disease. In Western societies, the …