Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution mapping of these modifications is …

Simple Summary Liquid biopsies provide a non-invasive means to diagnose and profile
tumors when tissue is not available. Sequence-based analysis of cell-free DNA (cfDNA) is …

Pancreatic cancer is often detected late, when curative therapies are no longer possible.
Here, we present non-invasive detection of pancreatic ductal adenocarcinoma (PDAC) by 5 …

Abstract DNA 5-hydroxymethylcytosine (5hmC) modification is known to be associated with
gene transcription and frequently used as a mark to investigate dynamic DNA methylation …

Hydroxymethylcytosine (5hmC) is an important epigenetic mark that regulates gene
expression. Charting the landscape of 5hmC in human tissues is fundamental to …

Background The main cause of cancer death is lung cancer (LC) which usually presents at
an advanced stage, but its early detection would increase the benefits of treatment. Blood is …

High-resolution detection of genome-wide 5-hydroxymethylcytosine (5hmC) sites of small-
scale samples remains challenging. Here, we present hmC-CATCH, a bisulfite-free, base …

The discovery of 5-hydroxymethylcytosine (5hmC) in mammalian genomes is a landmark in
epigenomics study. Similar to 5-methylcytosine (5mC), 5hmC is viewed as a critical …

Robust and clinically convenient biomarkers for cancer diagnosis, early detection, and
prognosis have great potential to improve patient survival and are the key to precision …

Analysis of circulating nucleic acids in bodily fluids, referred to as “liquid biopsies”, is rapidly
gaining prominence. Studies have shown that cell-free DNA (cfDNA) has great potential in …