Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

DNA damage can alter nucleotide sequences and lead to expression of dysfunctional
proteins that impact normal cellular physiology. Sources of DNA damage can be …

Nucleotide excision repair (NER) eliminates various structurally unrelated DNA lesions by a
multiwise'cut and patch'-type reaction. The global genome NER (GG-NER) subpathway …

Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which
threaten genome stability and cell viability. Cells have evolved two main repair pathways to …

Nucleotide excision repair (NER) is the main pathway used by mammals to remove bulky
DNA lesions such as those formed by UV light, environmental mutagens, and some cancer …

Genetic information is constantly being attacked by intrinsic and extrinsic damaging agents,
such as reactive oxygen species, atmospheric radiation, environmental chemicals, and …

Background Cells have evolved balanced mechanisms to protect themselves by initiating a
specific response to a variety of stress. The TP53 gene, encoding P53 protein, is one of the …

Structural changes to DNA severely affect its functions, such as replication and transcription,
and play a major role in age-related diseases and cancer. A complicated and entangled …

The response to DNA damage-stalled RNA polymerase II (RNAPIIo) involves the assembly
of the transcription-coupled repair (TCR) complex on actively transcribed strands. The …

Summary The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of
cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects …