Sensitive and selective biosensors for high‐throughput screening are having an increasing
impact in modern medical care. The establishment of robust protein biosensing platforms …

The superfamily of G protein-coupled receptors (GPCRs) mediates a wide range of
physiological responses and serves as an important category of drug targets. Earlier …

Technologies based on surface plasmon resonance (SPR) have allowed rapid, label‐free
characterization of protein‐protein and protein‐small molecule interactions. SPR has …

The molecular analysis of biomolecular-membrane interactions is central to understanding
most cellular systems but has emerged as a complex technical challenge given the …

H-, N-and K-ras4B are lipid-anchored, peripheral membrane guanine nucleotide binding
proteins. Recent work has shown that Ras proteins are laterally segregated into non …

Recent developments in the field of optical super-resolution techniques allow both a 10-fold
increase in resolution as well as an increased ability to quantify the number of labeled …

Analysis of the results from the human proteome project suggests> 30% of proteins are
membrane bound. 1 Membrane proteins (MPs) are in the core group responsible for signal …

The plasma membrane of cells contains a diverse array of lipids that provide important
structural and biological features. Glycolipids are typically a minor component of the cell …

We form artificial lipid bilayers suitable for single-molecule fluorescence microscopy by
contacting an aqueous droplet with a hydrogel support immersed in a solution of lipid in oil …

Adaptive immune responses are initiated by triggering of the T cell receptor. Single-
molecule imaging based on total internal reflection fluorescence microscopy at …