[HTML][HTML] Hyaluronic acid in the third millennium

A Fallacara, E Baldini, S Manfredini, S Vertuani - Polymers, 2018 - mdpi.com
Since its first isolation in 1934, hyaluronic acid (HA) has been studied across a variety of
research areas. This unbranched glycosaminoglycan consisting of repeating disaccharide …

Recent Advances in Clinical Translation of Intra‐Articular Osteoarthritis Drug Delivery Systems

CR DeJulius, S Gulati, KA Hasty… - Advanced …, 2021 - Wiley Online Library
Osteoarthritis (OA) is a degenerative disease of the joints and a leading cause of physical
disability in adults. Intra‐articular (IA) therapy is a popular treatment strategy for localized …

Nanoparticle-based inhibition of vascular endothelial growth factor receptors alleviates osteoarthritis pain and cartilage damage

K Ma, T Pham, J Wang, IS O-Sullivan, A DiCamillo… - Science …, 2024 - science.org
Osteoarthritis (OA) is characterized by cartilage damage, inflammation, and pain. Vascular
endothelial growth factor receptors (VEGFRs) have been associated with OA severity …

Corticosteroid injections for the treatment of osteoarthritis present a wide spectrum of effects ranging from detrimental to disease‐modifying: A systematic review of …

A Bensa, M Salerno, A Boffa… - Knee Surgery …, 2024 - Wiley Online Library
Purpose Aim of this systematic review of preclinical evidence was to determine the effects of
intra‐articular corticosteroid (CS) injections in joints affected by osteoarthritis (OA). Methods …

Intra‐articular injection of triamcinolone acetonide sustains macrophage levels and aggravates osteophytosis during degenerative joint disease in mice

MN Ferrao Blanco… - British Journal of …, 2022 - Wiley Online Library
Background and purpose Corticosteroids such as triamcinolone acetonide (TAA) are potent
drugs administered intra‐articularly as an anti‐inflammatory therapy to relieve pain …

Intra-articular administration of triamcinolone acetonide in a murine cartilage defect model reduces inflammation but inhibits endogenous cartilage repair

MA Wesdorp, S Capar… - … American Journal of …, 2022 - journals.sagepub.com
Background: Cartilage defects result in joint inflammation. The presence of proinflammatory
factors has been described to negatively affect cartilage formation. Purpose: To evaluate the …

Synovial membrane receptors as therapeutic targets: A review of receptor localization, structure, and function

SA Kleine, SC Budsberg - Journal of Orthopaedic Research, 2017 - Wiley Online Library
Joint pathology and degeneration is a significant cause of pain. The synovial membrane
plays an important role in maintenance of the joint, contributes to the pathology of many …

Chondroprotective Effects Of Intra-Articular Hyaluronic Acid And Triamcinolone In Murine Model Of Osteoarthritis.

N Ishaq, S Gul, M Gul, N Ata… - Journal of Ayub …, 2022 - search.ebscohost.com
Osteoarthritis is a heterogeneous disease of joints that affects mainly older population.
Definitive cure of osteoarthritis is still undiscovered. This study was designed to evaluate …

Radiographic Evaluation and Comparison of Chondroprotective Effects of Hyaluronic Acid and Triamcinolone in a Rat Model of Osteoarthritis

N Ishaq, MB Shahid, S Yasin, N Ata… - Journal of Islamic …, 2021 - journals.riphah.edu.pk
Objective: To evaluate and compare the chondroprotective effects of Hyaluronic acid and
triamcinolone at radiographic level in rat model of osteoarthritis. Study Design: Laboratory …

EVALUATION OF CHONDROPROTECTIVE EFFICACY OF TRIAMCINOLONE IN OSTEOARTHRITIS INDUCED RAT MODEL

N Ishaq, Q Mehdi, NS Bajwa, S Ali, B Shaheen… - Journal of University …, 2021 - jumdc.com
RESULTS: The mean gait score of the control group and treatment group was 3.25±. 707
and 2.25±. 463 with a p-value of 0.006 that is statistically significant. While mean …