Gut Microbiota: The Potential Key Target of TCM's Therapeutic Effect of Treating Different Diseases Using the Same Method—UC and T2DM as Examples

B Zhang, K Liu, H Yang, Z Jin, Q Ding… - Frontiers in Cellular and …, 2022 - frontiersin.org
Traditional Chinese herbal medicine often exerts the therapeutic effect of “treating different
diseases with the same method” in clinical practice; in other words, it is a kind of herbal …

Pharmacological actions, molecular mechanisms, pharmacokinetic progressions, and clinical applications of Hydroxysafflor Yellow A in antidiabetic research

X Zhang, D Shen, Y Feng, Y Li… - Journal of Immunology …, 2021 - Wiley Online Library
Hydroxysafflor yellow A (HSYA), a nutraceutical compound derived from safflower
(Carthamus tinctorius), has been shown as an effective therapeutic agent in cardiovascular …

[HTML][HTML] Dihydromyricetin alleviates methotrexate-induced hepatotoxicity via suppressing the‎ TLR4/NF-κB pathway and NLRP3 inflammasome/caspase 1 axis

AI Matouk, EM Awad, NFG El-Tahawy… - Biomedicine & …, 2022 - Elsevier
The anticancer drug methotrexate (MTX) is known to cause hepatotoxicity as a possibly fatal
adverse effect that hinders its clinical application. Although the natural flavonoid …

5-hydroxymethylfurfural alleviates inflammatory lung injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome activation

H Zhang, Z Jiang, C Shen, H Zou, Z Zhang… - Frontiers in Cell and …, 2021 - frontiersin.org
5-Hydroxymethylfurfural (5-HMF) is a common reaction product during heat processing and
the preparation of many types of foods and Traditional Chinese Medicine formulations. The …

[HTML][HTML] Inhibition of NF-κB ameliorates aberrant retinal glia activation and inflammatory responses in streptozotocin-induced diabetic rats

X Ding, Z Sun, Y Guo, W Tang, Q Shu… - Annals of Translational …, 2023 - ncbi.nlm.nih.gov
Background To determine the anti-inflammatory effects of IMD-0354, a specific NF-κB
blocker, on glial cells in rats with streptozotocin (STZ)-induced diabetic retinopathy (DR) …

Siling decoction ameliorates adenine-induced renal fibrosis in rats by the AKT/IKKβ/NFκB signaling pathway

L Zeng, Y Lin, H Chen, X Li, D Xie, Y Li, K Hu - Phytomedicine, 2024 - Elsevier
Abstract Objective Investigating how Siling decoction (SLD) mitigates fibrosis in rats with
chronic kidney disease CKD (chronic kidney disease) through network pharmacology …

Dapagliflozin ameliorated retinal vascular permeability in diabetic retinopathy rats by suppressing inflammatory factors

C Xu, H Li, Q Xu, K Zhao, M Hao, W Lin, X Ma… - Journal of Diabetes and …, 2024 - Elsevier
Background Diabetic retinopathy is a common microvascular complication of diabetes and
one of the major causes of blindness in the working-age population. Emerging evidence has …

Do cytokines associate periodontitis with metabolic disorders? An overview of current documents

R Aref Nezhad, H Motedayyen… - … , Metabolic & Immune …, 2022 - ingentaconnect.com
Periodontitis is an oral chronic inflammatory condition affecting the adult population
worldwide. Many microorganisms act as initiators for inducing inflammatory immune …

[PDF][PDF] Anti-alzheimer's activity of compounds from the methanolic extract of lawsonia inermis seeds: In vivo and in silico molecular docking studies

P Jyothi, K Yellamma - Indian Journal of Pharmaceutical Education and …, 2021 - ijper.org
Background: Alzheimer's disease (AD) hallmark feature is neurodegeneration due to the
accumulation of β-amyloid plaques and the formation of neurofibrillary tangles in the aged …

Novel and practical approaches to manage diet-induced metabolic disorders: Part-i

M Korivi, BR Liu - Current Pharmaceutical Design, 2020 - ingentaconnect.com
Metabolic syndrome (MetS) which is caused by poor dietary habits and sedentary behavior
is a serious global health problem. MetS is a cluster of risk factors, represented by central …