Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

Abstract Background The NaV1. 8 voltage-gated sodium channel, expressed in peripheral
nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548 …

The dorsal root ganglia–localized voltage-gated sodium (Nav) channel Nav1. 8 represents a
promising target for developing next-generation analgesics. A prominent characteristic of …

Voltage-gated sodium (Nav) channels are targeted by a number of widely used and
investigational drugs for the treatment of epilepsy, arrhythmia, pain, and other disorders …

The tremendous therapeutic potential of voltage-gated sodium channels (Navs) has been
the subject of many studies in the past and is of intense interest today. Nav1. 7 channels in …

Neuropathic pain (NeP) can result from sources as varied as nerve compression,
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …

The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …

Evidence from human genetic pain disorders shows that voltage-gated sodium channel α-
subtypes Nav1. 7, Nav1. 8 and Nav1. 9 are important in the peripheral signalling of pain …

After nerve injury maladaptive changes can occur in injured sensory neurons and along the
entire nociceptive pathway within the CNS, which may lead to spontaneous pain or pain …