Drug development and medicinal chemistry efforts toward SARS‐coronavirus and Covid‐19 therapeutics
AK Ghosh, M Brindisi, D Shahabi… - …, 2020 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐CoV‐2 infection is spreading at an alarming
rate and has created an unprecedented health emergency around the globe. There is no …
rate and has created an unprecedented health emergency around the globe. There is no …
Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study
AA Elfiky - Life sciences, 2020 - Elsevier
Aims A new human coronavirus (HCoV), which has been designated SARS-CoV-2, began
spreading in December 2019 in Wuhan City, China causing pneumonia called COVID-19 …
spreading in December 2019 in Wuhan City, China causing pneumonia called COVID-19 …
Anti-HCV, nucleotide inhibitors, repurposing against COVID-19
AA Elfiky - Life sciences, 2020 - Elsevier
Aims A newly emerged Human Coronavirus (HCoV) is reported two months ago in Wuhan,
China (COVID-19). Until today> 2700 deaths from the 80,000 confirmed cases reported …
China (COVID-19). Until today> 2700 deaths from the 80,000 confirmed cases reported …
SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective
AA Elfiky - Journal of Biomolecular Structure and Dynamics, 2021 - Taylor & Francis
New treatment against SARS-CoV-2 now is a must. Nowadays, the world encounters a huge
health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising …
health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising …
[HTML][HTML] Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach
Abstract Background The Severe acute respiratory syndrome-related coronavirus 2 (SARS-
CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the …
CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the …
[HTML][HTML] One-pot synthesis and molecular modeling studies of new bioactive spiro-oxindoles based on uracil derivatives as SARS-CoV-2 inhibitors targeting RNA …
The first outbreak in Wuhan, China, in December 2019 was reported about severe acute
coronaviral syndrome 2 (SARS-CoV-2). The global coronavirus disease 2019 (COVID-19) …
coronaviral syndrome 2 (SARS-CoV-2). The global coronavirus disease 2019 (COVID-19) …
Novel guanosine derivatives against MERS CoV polymerase: An in silico perspective
Abstract The Middle East Respiratory Syndrome Coronavirus (MERS CoV), also termed
camel flu, is a new viral infection that first reported in the year 2012 in the Middle East region …
camel flu, is a new viral infection that first reported in the year 2012 in the Middle East region …
Evaluation of potential anti-RNA-dependent RNA polymerase (RdRP) drugs against the newly emerged model of COVID-19 RdRP using computational methods
Introduction Despite all the efforts to treat COVID-19, no particular cure has been found for
this virus. Since developing antiviral drugs is a time-consuming process, the most effective …
this virus. Since developing antiviral drugs is a time-consuming process, the most effective …
[HTML][HTML] Potential drugs and remedies for the treatment of COVID-19: a critical review
COVID-19 disease with a high rate of contagious and highly nonspecific symptoms, is an
infectious disease caused by a newly discovered coronavirus. Most people who fall sick with …
infectious disease caused by a newly discovered coronavirus. Most people who fall sick with …
Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (Mpro) inhibitors to unveil a hope against COVID-19
Abstract SARS-CoV-2, a rapidly spreading new strain of human coronavirus, has affected
almost all the countries around the world. The lack of specific drugs against SARS-CoV-2 is …
almost all the countries around the world. The lack of specific drugs against SARS-CoV-2 is …