Abstract The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24
and IL-26. These cytokines are all members of the larger IL-10 family, but have been …

There are different operating definitions for acute-on-chronic liver failure (ACLF) in different
geographic regions. Consortia in Western countries have developed definitions that apply to …

Sepsis is a common and lethal syndrome: although outcomes have improved, mortality
remains high. No specific anti-sepsis treatments exist; as such, management of patients …

The acutely injured mammalian kidney mounts a cellular and molecular response to repair
itself. However, in patchy regions such intrinsic processes are impaired and dysregulated …

Rationale: Renal fibrosis is the terminal manifestation of chronic and irreversible renal
disease. Effective therapies other than dialysis are extremely limited. In this study, we …

Renal tissue injury initiates inflammatory and fibrotic processes that occur to promote
regeneration and repair. After renal injury, damaged tissue releases cytokines and …

Administration of human cord blood endothelial colony-forming cells (ECFCs) or their
exosomes protects mice against kidney ischemia/reperfusion injury. Here we studied the …

Increasing evidence has demonstrated the bidirectional link between acute kidney injury
(AKI) and chronic kidney disease (CKD) such that, in the clinical setting, the new concept of …

Renal ischemia-reperfusion (I/R) injury is the most common cause of AKI, which associates
with high mortality and has no effective therapy. ELABELA (ELA) is a newly identified 32 …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway is a multifaceted transduction system that regulates cellular responses to incoming …