Although frequently expressed in EBV-positive malignancies, the contribution of the
oncogenic latent membrane proteins, LMP1 and LMP2, to the pathogenesis of …

Neuronal precursor cell-expressed developmentally downregulated 4 (Nedd4) is the
prototypical protein in a family of E3 ubiquitin ligases that have a common domain …

CpG island promoter methylation of tumor suppressor genes is one of the most characteristic
abnormalities in EBV-associated gastric carcinoma (GC). Aberrant promoter methylation and …

SH2 domains serve as the prototype for a growing family of protein-interaction modules,
characteristic of polypeptides involved in transmitting signals from external and internal …

Ubiquitination of the chemokine receptor CXCR4 serves as a targeting signal for lysosomal
degradation, but the mechanisms mediating ubiquitination and lysosomal sorting remain …

Ubiquitin is important for nearly every aspect of cellular physiology. All viruses rely
extensively on host machinery for replication; therefore, it is not surprising that viruses …

Non-receptor type of protein-tyrosine kinase Syk contains 2 Src homology 2 (SH2) domains
in tandem and multiple autophosphorylation sites. Syk is activated upon binding of tandem …

Many cells latently infected with Epstein-Barr virus (EBV), including certain virus-associated
tumors, express latent membrane protein 2A (LMP2A), suggesting an important role for this …

p73, a member of the p53 family of transcription factors, is upregulated in response to DNA
damage, inducing cell cycle arrest and apoptosis. Besides indications that this p73 response …

The Epstein–Barr virus (EBV) is the first herpesvirus identified to be associated with human
cancers known to infect the majority of the world population. EBV-associated malignancies …