Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic
neurodegenerative diseases characterised by progressive spasticity of the lower limbs. The …

Recent advances in mitochondrial biology have revealed the high diversity and complexity
of proteolytic enzymes that regulate mitochondrial function. We have classified mitochondrial …

Mitochondria are essential metabolic hubs that dynamically adapt to physiological demands.
More than 40 proteases residing in different compartments of mitochondria, termed …

Anthracycline-induced cardiotoxicity (AIC) is a serious and common side effect of
anthracycline therapy. Identification of genes and genetic variants associated with AIC risk …

Over the past 30 years the mitochondrial permeability transition–the permeabilization of the
inner mitochondrial membrane due to the opening of a wide pore–has progressed from …

The accurate quantification of cellular and mitochondrial bioenergetic activity is of great
interest in medicine and biology. Mitochondrial stress tests performed with Seahorse …

Collapse of endocannabinoid (eCB) signaling in the amygdala contributes to stress-induced
anxiety, but the mechanisms of this effect remain unclear. eCB production is tied to the …

Protein tyrosine phosphatase 1B (PTP1B) inhibits insulin signaling, interfering with its
control of glucose homeostasis and metabolism. PTP1B activity is elevated in obesity and …

Significance: Mitochondria are complex dynamic organelles pivotal for cellular physiology
and human health. Failure to maintain mitochondrial health leads to numerous maladies that …

Dihydroorotate dehydrogenase (DHODH) oxidizes dihydroorotate to orotate for pyrimidine
biosynthesis, donating electrons to the ubiquinone (UQ) pool of mitochondria. DHODH has a …