Transcriptional regulation is a fundamental molecular mechanism involved in almost every
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …

Single-cell RNA sequencing (scRNA-seq) technology provides a powerful tool for
understanding complex biosystems at the single-cell and single-molecule level. The past …

Osteoporosis (OP) is a highly prevalent orthopedic condition in postmenopausal women and
the elderly. Currently, OP treatments mainly include bisphosphonates, receptor activator of …

Aims Dissecting complex interactions among transcription factors (TFs), microRNAs
(miRNAs) and long noncoding RNAs (lncRNAs) are central for understanding heart …

Aims MicroRNAs (miRNAs) are crucial for the post-transcriptional control of protein-
encoding genes and together with transcription factors (TFs) regulate gene expression; …

Complex disease is a cascade process which is associated with functional abnormalities in
multiple proteins and protein-protein interaction (PPI) networks. One drug one target has not …

Traditional Chinese medicine (TCM) formulas treat complex diseases through combined
botanical drugs which follow specific compatibility rules to reduce toxicity and increase …

Reconstructing gene regulatory networks (GRNs) from gene expression data is a
challenging problem. Existing GRN reconstruction algorithms can be broadly divided into …

DNA, RNA and protein are three major kinds of biological macromolecules with up to billions
of basic elements in such biological organisms as human or mouse. They function at …

Circadian rhythms govern various kinds of physiological and behavioral functions of the
living organisms, and disruptions of the rhythms are highly detrimental to health. Although …