Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …

The protein α‐synuclein has a central role in the pathogenesis of Parkinson's disease (PD).
In this review, we discuss recent results concerning its primary function, which appears to be …

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

Aberrant aggregation of the misfolded presynaptic protein, α-Synuclein (α-Syn) into Lewy
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …

The Alzheimer's disease (AD) afflicted brain is neuropathologically defined by extracellular
amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles composed of …

Abstract α-Synuclein is an abundant neuronal protein which localizes predominantly to
presynaptic terminals, and is strongly linked genetically and pathologically to Parkinson's …

Disorders characterized by α-synuclein (α-syn) accumulation, Lewy body formation and
parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

Alpha-synuclein is a presynaptic protein that forms abnormal cytoplasmic aggregates in
Lewy body disorders. Although nuclear alpha-synuclein localization has been described, its …

Presynaptic nerve terminals release neurotransmitters repeatedly, often at high frequency,
and in relative isolation from neuronal cell bodies. Repeated release requires cycles of …