Hiv dna integration
R Craigie, FD Bushman - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Retroviruses are distinguished from other viruses by two characteristic steps in the viral
replication cycle. The first is reverse transcription, which results in the production of a double …
replication cycle. The first is reverse transcription, which results in the production of a double …
Nuclear landscape of HIV-1 infection and integration
M Lusic, RF Siliciano - Nature Reviews Microbiology, 2017 - nature.com
To complete its life cycle, HIV-1 enters the nucleus of the host cell as reverse-transcribed
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …
[HTML][HTML] Rapid manufacturing of non-activated potent CAR T cells
S Ghassemi, JS Durgin, S Nunez-Cruz… - Nature biomedical …, 2022 - nature.com
Chimaeric antigen receptor (CAR) T cells can generate durable clinical responses in B-cell
haematologic malignancies. The manufacturing of these T cells typically involves their …
haematologic malignancies. The manufacturing of these T cells typically involves their …
[HTML][HTML] HIV-1 integration landscape during latent and active infection
The barrier to curing HIV-1 is thought to reside primarily in CD4+ T cells containing silent
proviruses. To characterize these latently infected cells, we studied the integration profile of …
proviruses. To characterize these latently infected cells, we studied the integration profile of …
Nuclear architecture dictates HIV-1 integration site selection
Long-standing evidence indicates that human immunodeficiency virus type 1 (HIV-1)
preferentially integrates into a subset of transcriptionally active genes of the host cell …
preferentially integrates into a subset of transcriptionally active genes of the host cell …
[HTML][HTML] HIV latency is established directly and early in both resting and activated primary CD4 T cells
L Chavez, V Calvanese, E Verdin - PLoS pathogens, 2015 - journals.plos.org
Highly active antiretroviral therapy (HAART) suppresses human immunodeficiency virus
(HIV) replication to undetectable levels but cannot fully eradicate the virus because a small …
(HIV) replication to undetectable levels but cannot fully eradicate the virus because a small …
Understanding HIV latency: the road to an HIV cure
MS Dahabieh, E Battivelli, E Verdin - Annual review of medicine, 2015 - annualreviews.org
Treatment with antiretroviral therapy dramatically increases the survival of HIV-infected
individuals. However, treatment has to be continued for life because it does not lead to the …
individuals. However, treatment has to be continued for life because it does not lead to the …
The molecular basis for human immunodeficiency virus latency
Although potent combination antiretroviral therapy can effectively block viral replication in
the host, human immunodeficiency virus (HIV) persists due to the existence of latent but …
the host, human immunodeficiency virus (HIV) persists due to the existence of latent but …
[HTML][HTML] A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers
DP Wong, NK Roy, K Zhang, A Anukanth… - Nature …, 2022 - nature.com
B cell-activating factor (BAFF) binds the three receptors BAFF-R, BCMA, and TACI,
predominantly expressed on mature B cells. Almost all B cell cancers are reported to …
predominantly expressed on mature B cells. Almost all B cell cancers are reported to …
[HTML][HTML] Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration
HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore
compartment in CD4+ T cells. However, the genomic features of these genes and the …
compartment in CD4+ T cells. However, the genomic features of these genes and the …