Cardiac muscle cells are equipped with specialized biochemical machineries for the rapid
generation of force and movement central to the work generated by the heart. During each …

Various human diseases can disrupt the balance between muscle contraction and
relaxation. Sarcomeric modulators can be used to readjust this balance either indirectly by …

The Z-disc acts as a protein-rich structure to tether thin filament in the contractile units, the
sarcomeres, of striated muscle cells. Proteins found in the Z-disc are integral for maintaining …

In the last few decades, many pathogenic or likely pathogenic genetic mutations in over
hundred different genes have been described for non-ischemic, genetic cardiomyopathies …

Restrictive cardiomyopathy (RCM), a potentially devastating heart muscle disorder, is
characterized by diastolic dysfunction due to abnormal muscle relaxation and myocardial …

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

Nemaline myopathy (NM) is a common form of congenital nondystrophic skeletal muscle
disease characterized by muscular weakness of proximal dominance, hypotonia, and …

The sarcomere is the smallest functional unit of muscle contraction. It is delineated by a
protein-rich structure known as the Z-disk, alternating with M-bands. The Z-disk anchors the …

The ability to generate patient-specific induced pluripotent stem cells (iPSCs) provides a
unique opportunity for modeling heart disease in vitro. In this study, we generated iPSCs …

The objective of this study was to explore the role of ferroptosis in the formation of calcium
oxalate (CaOx) kidney stones and the regulatory mechanism of the ankyrin repeat domain 1 …