A significant body of work has investigated the effects of acute exercise, defined as a single
bout of physical activity, on mood and cognitive functions in humans. Several excellent …

The subventricular zone (SVZ) of the anterolateral ventricle and the subgranular zone (SGZ)
of the hippocampal dentate gyrus are the two main regions of the adult mammalian brain in …

Components of the proteostasis network malfunction in aging, and reduced protein quality
control in neurons has been proposed to promote neurodegeneration. Here, we investigate …

Environmental enrichment (EE) increases dentate gyrus (DG) neurogenesis and brain-
derived neurotrophic factor (BDNF) levels. However, running is considered an element of …

Age‐related memory loss is considered to commence at middle‐age and coincides with
reduced adult hippocampal neurogenesis and neurotrophin levels. Consistent physical …

Accumulating evidence suggests that there is a rich cross-talk between the neuroimmune
system and neuroplasticity mechanisms under both physiological conditions and …

Alzheimer's disease (AD) and major depressive disorder (MDD) are highly prevalent
neuropsychiatric conditions with intriguing epidemiological overlaps. Depressed patients …

Recently, a single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor
(BDNF) gene (BDNF Val66Met) has been linked to the development of multiple forms of …

The adult mammalian brain can produce new neurons in a process called adult
neurogenesis, which occurs mainly in the subventricular zone (SVZ) and in the hippocampal …

The generation of new neurons in the adult brain is modulated by complex stimuli and a
broad range of extrinsic signals. It remains a mystery how stem cells and their progeny …