Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of
dramatic feats of regeneration, which have been studied for over 2 centuries. Recent …

One lens with which to understand the complex phenomenon of cancer is that of
developmental biology. Cancer is the inevitable consequence of a breakdown of the …

Regeneration requires the coordination of stem cells, their progeny and distant differentiated
tissues. Here, we present a comprehensive atlas of whole-body regeneration in Schmidtea …

Injury induces systemic responses, but their functions remain elusive. Mechanisms that can
rapidly synchronize wound responses through long distances are also mostly unknown …

Regenerative abilities vary dramatically across animals. Even amongst planarian flatworms,
well-known for complete regeneration from tiny body fragments, some species have …

For successful regeneration, the identity of the missing tissue must be specified according to
the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this …

Background The ability to assess gene function is essential for understanding biological
processes. Currently, RNA interference (RNAi) is the only technique available to assess …

INTRODUCTION Although all animals can heal wounds, some are capable of reconstructing
their entire bodies from small fragments of the original organism. Whole-body regeneration …

The ability to regenerate missing body parts exists throughout the animal kingdom.
Positional information is crucial for regeneration, but how it is harboured and used by …

Axial patterning during planarian regeneration relies on a transcriptional circuit that confers
distinct positional information on the two ends of an amputated fragment. The earliest known …