Development of Methods for the Determination of pKa Values
J Reijenga, A Van Hoof, A Van Loon… - Analytical chemistry …, 2013 - journals.sagepub.com
The acid dissociation constant (pKa) is among the most frequently used physicochemical
parameters, and its determination is of interest to a wide range of research fields. We …
parameters, and its determination is of interest to a wide range of research fields. We …
A systematic review of various pKa determination techniques
GE Han, R Priefer - International Journal of Pharmaceutics, 2023 - Elsevier
The pK a values of functional groups is crucial in determining the pharmacokinetic
properties of a drug, affecting its absorption and thus bioavailability. This physicochemical …
properties of a drug, affecting its absorption and thus bioavailability. This physicochemical …
Arginine: Its pKa value revisited
CA Fitch, G Platzer, M Okon… - Protein …, 2015 - Wiley Online Library
Using complementary approaches of potentiometry and NMR spectroscopy, we have
determined that the equilibrium acid dissociation constant (pKa value) of the arginine …
determined that the equilibrium acid dissociation constant (pKa value) of the arginine …
pH-dependent random coil 1H, 13C, and 15N chemical shifts of the ionizable amino acids: a guide for protein pK a measurements
G Platzer, M Okon, LP McIntosh - Journal of biomolecular NMR, 2014 - Springer
The p K a values and charge states of ionizable residues in polypeptides and proteins are
frequently determined via NMR-monitored pH titrations. To aid the interpretation of the …
frequently determined via NMR-monitored pH titrations. To aid the interpretation of the …
Molecular binding between anthocyanins and pectic polysaccharides–Unveiling the role of pectic polysaccharides structure
A Fernandes, J Oliveira, F Fonseca… - Food …, 2020 - Elsevier
The interaction between cyanidin-3-O-glucoside and four citrus pectic fractions was
investigated using a combined molecular approach, including isothermal titration calorimetry …
investigated using a combined molecular approach, including isothermal titration calorimetry …
Constant pH molecular dynamics in explicit solvent with λ-dynamics
S Donnini, F Tegeler, G Groenhof… - Journal of chemical …, 2011 - ACS Publications
pH is an important parameter in condensed-phase systems, because it determines the
protonation state of titratable groups and thus influences the structure, dynamics, and …
protonation state of titratable groups and thus influences the structure, dynamics, and …
Synthesis and activity of biomimetic biofilm disruptors
Biofilms are often associated with human bacterial infections, and the natural tolerance of
biofilms to antibiotics challenges treatment. Compounds with antibiofilm activity could …
biofilms to antibiotics challenges treatment. Compounds with antibiofilm activity could …
Self-assembling, supramolecular chemistry and pharmacology of amphotericin B: Poly-aggregates, oligomers and monomers
R Fernández-García, JC Muñoz-García… - Journal of Controlled …, 2022 - Elsevier
Antifungal drugs such as amphotericin B (AmB) interact with lipids and phospholipids
located on fungal cell membranes to disrupt them and create pores, leading to cell apoptosis …
located on fungal cell membranes to disrupt them and create pores, leading to cell apoptosis …
Impact of grape pectic polysaccharides on anthocyanins thermostability
A Fernandes, E Brandão, F Raposo, É Maricato… - Carbohydrate …, 2020 - Elsevier
The impact of grape pectic polysaccharides on malvidin-3-O-β-d-glucoside thermostability
was evaluated in model solutions. Pectic polysaccharides richer in homogalacturonan …
was evaluated in model solutions. Pectic polysaccharides richer in homogalacturonan …
[PDF][PDF] Polyaniline doped with protonic acids: optical and morphological studies
In this work Polyaniline and its doped state with microfiber morphologies were easily
synthesized by chemical route under the oxidative polymerization, in which the …
synthesized by chemical route under the oxidative polymerization, in which the …