During the cell cycle, DNA suffers several lesions that need to be repaired prior to entry into
mitosis to preserve genome integrity in daughter cells. Toward this aim, cells have …

Background: Cyclin B1 has an important role in the G 2–M phase transition of the cell cycle.
Wee1 delays mitosis by suppressing the activity of the Cyclin B1/cdc2 complex. The …

During development, co-ordinate regulation of cell cycle exit and differentiation of neuronal
precursors is essential for generation of appropriate number of neurons and proper wiring of …

Genome maps are crucial tools in human genetic research, providing known landmarks for
locating disease genes and frameworks for large-scale sequencing. Radiation hybrid …

We present a high resolution radiation hybrid map of human chromosome 11 using 506
sequence tagged sites (STSs) scored on a panel of 86 radiation hybrids. The 506 STSs fall …

Background: Meiotic recombination events do not occur randomly along a chromosome, but
appear to be restricted to specific regions. In addition, some regions in the genome undergo …

Familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is a rare, autosomal
recessive disease of unregulated insulin secretion, defined by elevations in serum insulin …

The human ST5 gene encodes three proteins with predicted molecular masses of 126, 82,
and 70 kDa. These widely expressed proteins share a C-terminal region that bears …

Background: Although multiple methods of tongue reduction have been described, recent
literature suggests that the central reductions may be more favorable in patients with …

Multiple studies have underscored the importance of loss of tumor suppressor genes in the
development of human cancer. To identify these genes, we used somatic cell hybrids in a …