Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine
binding site is one of the most important pockets for potential tubulin polymerization …

The vital roles of microtubule in mitosis and cell division make it an attractive target for
antitumor therapy. Colchicine binding site of tubulin is one of the most important pockets that …

Sulfonamides have been in clinical use for many years, and the development of bioactive
substances containing the sulfonamide subunit has grown steadily in view of their important …

The combretastatins are isolated from South African tree combretum caffrum kuntze. The
lead compound combretastatin A-4 has displayed remarkable cytotoxic effect in a wide …

Abstract The styryl (Ph‐CH= CH‐R) group is widely represented in medicinally important
compounds, including drugs, clinical candidates, and molecular probes as it positively …

Cancer is one of the most critical problems of public health in the world and one of the main
challenges for medicine. Different biological effects have been reported for sulfonamide …

Imidazolinones were obtained in good yields by intramolecular hydroamination of N-alkoxy
ureas in the presence of an organic photocatalyst and an inorganic base. In this reaction, the …

Tubulin, the microtubules and their dynamic behavior are amongst the most successful
antitumor, antifungal, antiparasitic, and herbicidal drug targets. Sulfonamides are exemplary …

A series of novel Schiff bases-based TMP moieties have been designed and synthesized as
potential anticancer agents. The target Schiff bases were screened for their cytotoxic activity …

(3-Alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides (PAIB-SAs) are members of
a new family of prodrugs bioactivated by cytochrome P450 1A1 (CYP1A1) in breast cancer …