Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Tumor necrosis factor (TNF) is a multifunctional cytokine that plays important roles in diverse
cellular events such as cell survival, proliferation, differentiation, and death. As a pro …

PS-341, also known as Velcade or Bortezomib, represents a new class of anticancer drugs
which has been shown to potently inhibit the growth and/or progression of human cancers …

Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy and is a major
cause of cancer morbidity and mortality worldwide. Carcinoma of the uterine cervix is the …

Cytokines are critical mediators of inflammation and host defenses. Regulation of cytokines
can occur at various stages of gene expression, including transcription, mRNA export, and …

The NF-kB pathway, which is ubiquitous in nature and evolutionarily conserved in most cell
types, 1 controls the expression of genes involved in multiple physiologic processes …

A high proportion of oncogenes and tumor suppressor genes encode transcription factors.
Deregulated expression or activation and inactivation of transcription factors as well as …

Opinion statement The complex syndrome of cancer cachexia (CC) that occurs in 50% to
80% cancer patients has been identified as an independent predictor of shorter survival and …

Omega-3 fatty acids (ω3-FA) were shown to attenuate growth and induce apoptosis in a
variety of human cancer cell lines derived from colonic, pancreatic, prostate, and breast …

Advances in our understanding of the mechanisms by which tumor cells detect drug-induced
DNA damage leading to apoptotic death have aided in the design of novel, potentially more …