[HTML][HTML] Broad targeting of resistance to apoptosis in cancer
Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …
Tumor necrosis factor and cancer, buddies or foes?1
X Wang, Y Lin - Acta Pharmacologica Sinica, 2008 - Wiley Online Library
Tumor necrosis factor (TNF) is a multifunctional cytokine that plays important roles in diverse
cellular events such as cell survival, proliferation, differentiation, and death. As a pro …
cellular events such as cell survival, proliferation, differentiation, and death. As a pro …
Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell …
PS-341, also known as Velcade or Bortezomib, represents a new class of anticancer drugs
which has been shown to potently inhibit the growth and/or progression of human cancers …
which has been shown to potently inhibit the growth and/or progression of human cancers …
Human papillomavirus and disease mechanisms: relevance to oral and cervical cancers
Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy and is a major
cause of cancer morbidity and mortality worldwide. Carcinoma of the uterine cervix is the …
cause of cancer morbidity and mortality worldwide. Carcinoma of the uterine cervix is the …
Control of cytokine mRNA expression by RNA-binding proteins and microRNAs
V Palanisamy, A Jakymiw… - Journal of dental …, 2012 - journals.sagepub.com
Cytokines are critical mediators of inflammation and host defenses. Regulation of cytokines
can occur at various stages of gene expression, including transcription, mRNA export, and …
can occur at various stages of gene expression, including transcription, mRNA export, and …
Targeting the NF-κB pathway in cancer therapy
DJ Erstad, JC Cusack - Surgical Oncology Clinics, 2013 - surgonc.theclinics.com
The NF-kB pathway, which is ubiquitous in nature and evolutionarily conserved in most cell
types, 1 controls the expression of genes involved in multiple physiologic processes …
types, 1 controls the expression of genes involved in multiple physiologic processes …
Targeting transcription factors for cancer gene therapy
TA Libermann, LF Zerbini - Current gene therapy, 2006 - ingentaconnect.com
A high proportion of oncogenes and tumor suppressor genes encode transcription factors.
Deregulated expression or activation and inactivation of transcription factors as well as …
Deregulated expression or activation and inactivation of transcription factors as well as …
[HTML][HTML] Cancer cachexia: traditional therapies and novel molecular mechanism-based approaches to treatment
NB Kumar, A Kazi, T Smith, T Crocker, D Yu… - … treatment options in …, 2010 - Springer
Opinion statement The complex syndrome of cancer cachexia (CC) that occurs in 50% to
80% cancer patients has been identified as an independent predictor of shorter survival and …
80% cancer patients has been identified as an independent predictor of shorter survival and …
Anticancer actions of omega-3 fatty acids-current state and future perspectives
M Wendel, AR Heller - Anti-Cancer Agents in Medicinal …, 2009 - ingentaconnect.com
Omega-3 fatty acids (ω3-FA) were shown to attenuate growth and induce apoptosis in a
variety of human cancer cell lines derived from colonic, pancreatic, prostate, and breast …
variety of human cancer cell lines derived from colonic, pancreatic, prostate, and breast …
Harnessing apoptosis for improved anticancer gene therapy
DJ Waxman, PS Schwartz - Cancer research, 2003 - AACR
Advances in our understanding of the mechanisms by which tumor cells detect drug-induced
DNA damage leading to apoptotic death have aided in the design of novel, potentially more …
DNA damage leading to apoptotic death have aided in the design of novel, potentially more …