The use of light absorbing chemicals to cause photoreactions in biological systems dates
back to at least 1900 when Raab reported a lethal effect on paramecium exposed to light …

Photodynamic therapy (PDT) is the treatment of malignant lesions with visible light following
the systemic administration of a tumor-localizing photosensitizer. Pharmacological and …

Selective in vitro photodestruction of HPB-ALL human T-cell leukemia cells was
accomplished using the photosensitizer chlorin e6 coupled through dextran molecules to an …

Abstract Hematoporphyrin (5 mg/ml), administered intravenously to tumor-bearing patients,
becomes associated with different serum proteins, including lipoproteins (mainly HDL) …

The oxygen dependence of hematoporphyrin derivative (HPD)-induced photoinactivation of
Chinese hamster V79 cells was examined. Cells were treated with HPD (25 µg/ml) for 2 h …

The mechanisms of cellular uptake, subcellular localization, and cellular retention kinetics of
the photosensitizers photofrin II (PfII), mono‐l‐aspartyl chlorin e6 (MACE), and chloro …

Cells of the line NHIK 3025 were incubated with the tumor-localizing porphyrin preparation
DHE (PHotofrin II). Exposure of light within the porphyrin absorption spectrum resulted in (a) …

Abstract Background and Objectives Interstitial photodynamic therapy (PDT) is an emerging
modality for the treatment of solid organ disease. Our group at the University of …

Photodynamic eradication of tumour cells depends on the presence of a photosensitizer and
light delivery to the cells. The present study investigated the influence of fractionated light …

The effects of hematoporphyrin derivative, light, and cobalt 60 (60Co) irradiation were
studied in a rat glioma model using an in vivo and an in vitro clonogenic assay. There was …