Cancer classification aims to provide an accurate diagnosis of the disease and prediction of
tumor behavior to facilitate oncologic decision making. Traditional breast cancer …

Breast cancer is a heterogeneous disease and differs greatly among different patients
(intertumor heterogeneity) and even within each individual tumor (intratumor heterogeneity) …

Breast cancers are complex ecosystems of malignant cells and the tumour
microenvironment. The composition of these tumour ecosystems and interactions within …

INTRODUCTION Cancer is one of the leading causes of death worldwide. Although the 2%
of the human genome that encodes proteins has been extensively studied, much remains to …

Breast cancer (BC) comprises multiple distinct subtypes that differ genetically,
pathologically, and clinically. Here, we describe a robust protocol for long-term culturing of …

The genomic landscape of breast cancer is complex, and inter-and intra-tumour
heterogeneity are important challenges in treating the disease. In this study, we sequence …

Genomic alterations shape cell phenotypes and the structure of tumor ecosystems in poorly
defined ways. To investigate these relationships, we used imaging mass cytometry to …

Background Immune infiltration of breast tumours is associated with clinical outcome.
However, past work has not accounted for the diversity of functionally distinct cell types that …

Whole-genome sequencing (WGS) brings comprehensive insights to cancer genome
interpretation. To explore the clinical value of WGS, we sequenced 254 triple-negative …

Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to
subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been …