Catalytic enantioselective aldol reactions

Y Yamashita, T Yasukawa, WJ Yoo… - Chemical Society …, 2018 - pubs.rsc.org
Recent developments in catalytic asymmetric aldol reactions have been summarized.
Enantioselective aldol reactions are important methods to synthesize β-hydroxy carbonyl …

Catalytic asymmetric aldol reactions in aqueous media–a 5 year update

J Mlynarski, S Baś - Chemical Society Reviews, 2014 - pubs.rsc.org
Asymmetric reactions in water and in aqueous solutions have become an area of fast
growing interest recently. Although for a long time neglected as a medium for organic …

Enantioselective organocatalytic aldol reaction using small organic molecules

V Bisai, A Bisai, VK Singh - Tetrahedron, 2012 - Elsevier
Enantioselective reactions catalyzed by small organic molecules (asymmetric
organocatalysis) have emerged as one of the most elegant cutting-edge strategies of …

Recent applications of organocatalysts in asymmetric aldol reactions

MM Heravi, S Asadi - Tetrahedron: Asymmetry, 2012 - Elsevier
The asymmetric aldol reaction is one of the most powerful synthetic tools for carbon–carbon
bond-forming reactions. This method provides a beneficial route to access chiral β-hydroxy …

Direct asymmetric aldol reactions inspired by two types of natural aldolases: Water-compatible organocatalysts and ZnII complexes

J Paradowska, M Pasternak, B Gut, B Gryzło… - 2011 - ACS Publications
In this article the utility of water-compatible amino-acid-based catalysts was explored in the
development of diastereo-and enantioselective direct aldol reactions of a broad range of …

Water: the most versatile and nature's friendly media in asymmetric organocatalyzed direct aldol reactions

S Bhowmick, A Mondal, A Ghosh, KC Bhowmick - Tetrahedron: Asymmetry, 2015 - Elsevier
The aldol reaction is an excellent synthetic tool to construct β-hydroxy carbonyl skeletons.
The asymmetric version of this reaction has been developed for the synthesis of …

Sequential reductive amination‐hydrogenolysis: a one‐pot synthesis of challenging chiral primary amines

TC Nugent, DE Negru, M El‐Shazly… - Advanced Synthesis …, 2011 - Wiley Online Library
Difficult‐to‐access chiral primary amines were formed in good to high yield and ee using a
rare example of a one‐pot synthesis from prochiral ketones (sequential reductive amination …

Enzyme inhibitory, antioxidant and antibacterial potentials of synthetic symmetrical and unsymmetrical thioureas

S Naz, M Zahoor, MN Umar, B Ali, R Ullah… - Drug Design …, 2019 - Taylor & Francis
Background In this study, 2 symmetrical and 3 unsymmetrical thioureas were synthesized to
evaluate their antioxidant, antibacterial, antidiabetic, and anticholinesterase potentials …

Chiral picolylamines for Michael and aldol reactions: probing substrate boundaries

TC Nugent, A Bibi, A Sadiq, M Shoaib… - Organic & …, 2012 - pubs.rsc.org
Here we report on inroads concerning increased substrate breadth via the picolylamine
organocatalyst template, a vicinal chiral diamine based on a pyridine-primary amine motif …

Chitosan aerogel beads as a heterogeneous organocatalyst for the asymmetric aldol reaction in the presence of water: An assessment of the effect of additives

C Gioia, A Ricci, L Bernardi, K Bourahla… - European Journal of …, 2013 - Wiley Online Library
The catalytic properties of chitosan aerogel for the direct asymmetric aldol reaction in water
assisted by various surfactants and acid co‐catalysts have been evaluated by employing a …